Marco Fato

Associate Professor

Address Viale Causa, 13 - 16145 Genova
Phone (office) (+39) 010353 - 2789
Phone (laboratory) (+39) 010353 - 2789
Fax (+39) 010353 - 2948
Mobile (+39) 3204218901
Research Programs


Marco Massimo Fato was born on September, the 22th, 1963 in Genoa, Italy. Scientific High School Degree at Liceo G.D. Cassini of Genoa, Italy, in 1982 (48/60). Laurea degree in Electronic Engineering at the University of Genoa, Italy, in 1988 (106/110). Scientific collaborator in the Laboratory of Bioengineering and anthropomorphic robot of University of Genoa, Department of Communication, Computer and Systems Science (DIST), from 1989 to 1990. He has worked at Video Display Systems (VDS SpA) of Florence as developer of CAD and CAM systems in UNIX for applications in industrial robotics, from 1990 to 1992. Research grant on Quantitative Microscopy, Collaboration with Leica S.p.A from 1992 to 1993. PhD, University of Genoa, Italy, in 1996. Research grant with Finsiel S.p.A. at University of Genoa, Italy from 1996 to 1997. Scientific collaborator at the BioLab, Bioengineering and Bioimages Laboratory of DIBRIS (University of Genoa), from 1998 to 2005. Since 2006 Associate Professor of... read more


  • F. Beltrame, P. Ramoino, M. Fato, M. U. Delmonte Corrado, G. Marcenaro, T. Crippa Franceschi, “3D reconstruction of Paramecium primaurelia oral apparatus through confocal laser scanning optical microscopy”, SPIE Proceed. Series, V. 1660, pp. 728-736, 1992.
  • F. Beltrame, P. Ramoino, M. Fato, M. U. Delmonte Corrado, G. Marcenaro, T. Crippa Franceschi, “Three-dimensional reconstruction of Paramecium primaurelia oral apparatus through confocal laser scanning optical microscopy”, Micron and Microscopica Acta, V. 23, N. 4, pp. 403-412, 1992.
  • F. Beltrame, L. Cotta, M. De Ceglia, M. Fato, G. Marcenaro, D. Caramella, M. Del Sarto, I. Sobel, “Use of 24-bit false-color imagery to enhance visualization of multiparameter MR images”, Magnetic Resonance Materials in Physics, Biology, and Medicine (MAG*MA), V. 2, N. 4, pp. 551-558, 1994.
  • P. Ramoino, G. Marcenaro, M. Fato, F. Beltrame, “Spatio-temporal analysis of single-celled organism (protozoa) structures via confocal microscopy”, SPIE Proceed. Series, V. 2184, pp. 138-147, 1994.
  • F. Beltrame, A. Diaspro, M. Fato, I. Martin, P. Ramoino, I. Sobel, “Use of stereo vision and 24-bit false colour imagery to enhance visualization of multimodal confocal images”, SPIE Proceed. Series, V. 2412, pp. 222-229, 1995.
  • P. Ramoino, F. Beltrame, M. Fato, “Image analysis of lysosomal activity during the early clonal life of Paramecium primaurelia”, FEMS Microbiology Letters, V. 125, pp. 57-62, 1995.
  • P. Ramoino, F. Beltrame, M. Fato, G. Marcenaro, “Acid phosphatase activity in mating type I and mating type II cell lines of Paramecium primaurelia”, European Journal of Histochemistry., V. 39, pp. 157-164, 1995.
  • Diaspro, F. Beltrame, M. Fato, P. Ramoino, “Characterizing biostructures and cellular events in 2D/3D”, IEEE Engineering in Medicine and Biology Magazine, V. 15, N. 1, pp. 92-100, 1996.
  • Diaspro, F. Beltrame, M. Fato, A. Palmeri, P. Ramoino, “Confocal laser scanning microscopy (CLSM) image fusion to study dynamics and networking processes in biological systems through the use of a bioimage-oriented interface”, Journal of Computer Assisted Microscopy, V. 8, N. 3, pp. 119-129, 1996.
  • P. Ramoino, F. Beltrame, A. Diaspro, M. Fato, “Time-variant analysis of organelle and vescicle movement during phagocytosis in Paramecium primaurelia by means of fluorescence confocal laser scanning microscopy”, Microscopy Research and Technique, V. 35, N. 5, pp. 377-384, 1996.
  • Viarengo, R. Accomando, I. Ferrando, F. Beltrame, M. Fato, G. Marcenaro, “Heavy metal effects on cytosolic free Ca2+ level in the marine protozoan Euplotes crassus evaluated by confocal laser scanning microscopy”, Comparative Biochemistry and Physiology, V. 113C, N. 2, pp. 161-168, 1996.
  • F. Beltrame, M. Fato, E. Raposio, I. Sobel, “Recent results in color compositing of three-parameter magnetic resonance scans as a preoperative aid to the management of upper limb sarcomas”, Magnetic Resonance in Physics, Biology, and Medicine (MAG*MA), V. 5, pp. 289-298, 1997.
  • Diaspro, F. Beltrame, M. Fato, A. Palmeri, P. Ramoino, “Studies on the structure of sperm heads of Eledone cirrhosa by means of CLSM linked to bioimage-oriented devices”, Microscopy Research and Technique, V. 36, pp. 159-164, 1997.
  • Diaspro, L. Gallus, M. Fato, R. Rollandi, G. Tagliafierro, "Three-dimensional reconstruction of FMRM-amide immunopositive neurons in the ventral ganglion of the barnacle Balanus amphitrite (Cirripedia, Crustacea)”, European Journal of Histochemistry, V. 41/suppl.2, pp. 99-100, 1997.
  • P. Ramoino, F. Beltrame, A. Diaspro, M. Fato, “Trichocyst membrane fate in living Paramecium primaurelia visualized by multimodal confocal imaging”, European Journal of Cell Biology, V. 74, pp. 79-84, 1997.
  • P. Ramoino, F. Beltrame, A. Diaspro, M. Fato, “Lectin internalization and intracellular transport in Paramecium primaurelia cells blocked in phagocytic activity studied through CLSM”, European Journal of Histochemistry, V. 41/suppl.2, pp. 183-184, 1997.
  • P. Ramoino, A. Diaspro, F. Beltrame, M. Fato, “The use of CLSM to visualize the membrane flow during phagocytosis and exocytosis in Paramecium primaurelia”, European Journal of Histochemistry, V. 41/suppl. 2, pp. 103-104, 1997.
  • P. Ramoino, A. Diaspro, M. Fato, F. Beltrame, “Cytofluorometry and fluorescence confocal laser scanning microscopy (CLSM) in the study of neutral lipid dynamics in Paramecium primaurelia mating types during cell line development”, Cytometry, V. 35, N. 4, pp. 346-352, 1999.
  • P. Ramoino, A. Diaspro, M. Fato, F. Beltrame, M. Robello, “Changes in the endoplasmic reticulum structure of Paramecium primaurelia in relation to different cellular physiological states”, Journal of Photochemistry and Photobiology, V. 54, pp. 35-42, 2000.
  • F. Beltrame, G. De Leo, M. Fato, F. Masulli, A. Schenone, “A three-dimensional visualization and navigation tool for diagnostic and surgical planning applications”, SPIE Proceed. Series, V. 4319, pp. 507-514, 2001.
  • L. Gallus, A. Diaspro, F. Beltrame, M. Fato, G. Tagliafierro, “Three-dimensional computer-aided reconstruction of FMFRFamide immunopositive neuron distribution in the ventral ganglion of the barnacle Balanus amphitrite (Cirripedia, Crustacea)”, European Journal Histochemistry, V. 45, pp. 95-104, 2001.
  • P. Ramoino, P. Fronte, M. Fato, F. Beltrame, M. Robello, A. Diaspro, “Fluid phase and receptor-mediated endocytosis in Paramecium primaurelia by fluorescence confocal laser scanning microscopy”, European Biophysical Journal, V. 30, pp. 305-312, 2001.
  • Diaspro, P. Fronte, M. Raimondo, M. Fato, G. De Leo, F. Beltrame, F. Cannone, G. Chirico, P. Ramoino,”Functional imaging of living Paramecium by means of confocal and two-photon excitation fluorescence microscopy”, SPIE Proceed. Series, 2002.
  • P. Ramoino, P. Fronte, M. Fato, F. Beltrame, A. Diaspro, ”Mapping cholesteryl ester uptake and intracellular flow in Paramecium by confocal fluorescence microscopy”, Journal of Microscopy, Vol. 208, pp.167-176, 2002.
  • P. Ramoino, P. Fronte, F. Beltrame, A. Diaspro, M. Fato, L. Raiteri, S. Stigliani, C. Usai, “Swimming behavior regulation by GABAB receptors in Paramecium”, Expt Cell Res. N. 291,  pp. 398-405, 2003.
  • G. De Leo, M. Ponder, T. Molet, M. Fato, D. Thalmann, N. Magnenat-Thalmann, F. Bermano, F. Beltrame, “A virtual reality system for training of volunteers involved in health emergency situations”, CyberPsychology & Behavior, Vol. 6, N.3, pp. 267-274, ISSN: 1094-9313, June 2003.
  • F. Difato, F. Mazzone, S. Scaglione, M. Fato, F.Beltrame, L. Kubinova, J. Janacek, P. Ramoino, G. Vicidomini, A. Diaspro, “Improvement in volume estimation from confocal sections after image deconvolution”, Microscopy Research and Technique, Vol. 64, pp. 151-155 , 2004.
  • P. Ramoino, S. Scaglione, A. Diaspro, F. Beltrame, M. Fato, C. Usai, “GABAA receptor subunits identified in Paramecium by immunofluorescence confocal microscopy”, FEMS Microbiology Letters, V. 238, pp. 449-453, 2004.
  • Manganas, M. Tsiknakis, E. Leisch, M. Ponder, T. Molet, B. Herbelin, N. Magnenat-Thalmann, D. Thalmann, M. Fato, A, Schenone, “The JUST VR Tool: An Innovative Approach to Training Personnel for Emergency Situations Using Virtual reality Techniques”, The Journal on Information Technology in Healthcare, Vol. 2(6), pp.399-412, 2004.
  • Porro, A. Schenone, M. Fato, E. Raposio, E. Molinari, F. Beltrame, "An integrated environment for plastic surgery support: building virtual patients, simulating interventions, and supporting intraoperative decisions", Computerized Medical Imaging and Graphics, Vol. 25, pp. 285-294, 2005.
  • G. De Leo, S. Krishna, S. Boren, M. Fato, I. Porro, E. A. Balas, "Web and Computer Telephone-Based Diabetes Education: Lessons Learnet from the Development and Use of a Call Center", Journal of Medical Systems, Vol. 29, N. 4, pp. 343-354, August 2005.
  • E. Molinari, M. Fato, G. De Leo, D. Riccardo, F. Beltrame, "Simulation of the Biomechanical Behaviour of the Skin in Virtual Surgical  Applications by Finite Elements Method", IEEE Transactions on Biomedical Engineering, Vol. 52, No. 9, pp.1514-1521, September 2005.
  • P. Ramoino, C. Usai, F. Beltrame, M. Fato, L. Gallus, G. Tagliafierro,  R. Magrassi, A. Diaspro, "GABAB receptor intracellular trafficking after internalization in Paramecium", Microscopy Research and Technique, vol. 68, pp. 290-295, 2005.
  • P. Ramoino, L.,Gallus, F. Beltrame, A. Diaspro, M. Fato, P. Rubini, S. Stigliani, G. Bonanno, C. Usai, “Endocytosis of GABAB receptors modulates membrane excitability in the single-celled organism Paramecium”, Journal of Cell Science, Vol. 119, pp. 2056-2064, 2006.
  • Porro, L. Torterolo, L. Corradi, M. Fato, A. Papadimitropoulos, S. Scaglione, A. Schenone, F. Viti, “A Grid based solution for management and analysis of microarrays in distributed experiments”, BMC Bioinformatics 2007, 8(Suppl 1):S7 doi:10.1186/1471-2105-8-S1-S7.
  • L. Girosi, S. Ferrando, F. Beltrame, G. Ciancia, A. Diaspro, M. Fato, M. Magnone, L. Reiteri, P. Ramoino, G. Tagliaferro, “Gamma-aminobutryc acid and related molecules in the sea fan Funicella cavolini (Cnidaria: Octocorallia): a biochemical and immunohistochemical approach”, Cell. Tissue Res., Vol. 329, pp. 187-196, 2007.
  • P. Ramoino, L. Gallus, S. Palazzi, L. Reiteri, A. Diaspro, M. Fato, G. Bonanno, G. Tagliaferro, C. Ferretti, R. Manconi, “The GABAergic-Like System in the Merine Demosponge Chondrilla nucula”, Microscopy Research and Technique, Vol. 70, pp. 944-951, 2007.
  • P. Ramoino, C. Usai, S. Maccione, F. Beltrame, A. Diaspro, M. Fato, G. Guella,  F.  Dini, “Effect of the bioactive metabolite euplotin C on phagocytosis and fluid-phase endocytosis in the single-celled eukaryote Paramecium.  Aquatic Toxicology, Vol. 85, pp. 67-75, 2007.
  • L. Corradi, M. Fato, I. Porro, S. Scaglione, L. Torterolo “A Web-based and Grid-enabled dChip version for the analysis of large sets of gene expression data” BMC Bioinformatics, Vol. 9:480, 2008.
  • S. Scaglione, D. Wendt, S. Miggino, A. Papadimitropoulos, , M. Fato, R. Quarto and I. Martin “Effects of flow-induced shear and calcium-phosphate coating on human bone marrow stromal cells cultured in a defined 2D model system” Journal of Biomedical Material Research Part A, 2008 Aug;86(2):411-9.
  • S. Scaglione, C. Ilengo, M. Fato and R. Quarto “Hydroxyapatite-coated polycaprolacton wide mesh as a  model of open structure for bone regeneration”, Tissue Engineering Part A Vol. 15(1): 155-163,  January 1, 2009.
  • R. Valente, A. Testi, E. Tanfani, M. Fato, I. Porro, M. Santo, G. Santori,  G. C. Torre, G. L. Ansaldo, “A model to prioritize access to elective on the base of clinical urgency and waiting time”, BMC Health Services Research., Vol.9:1, January , 2009.
  • L. Corradi,  V. Mirisola, I. Porro,  L. Torterolo, M. Fato, P. Romano, U. Pfeffer, “Survival Online: A Web-based service for the analysisof correlations between gene expression and clinical and follow-up data”, BMC Informatics Vol. 10 (Suppl 12):S10 doi: 10.1186/1471-2105-10-S12-S10.
  • Testi A, Tànfani E, Valente R, Fato M, Porro I. “A web-based system to manage elective waiting lists: efficiency and equity issues” , International  Journal of  Healthcare Technology and Management, Vol. 10, pp. 277-288, Nos. 4/5, 2009.
  • Ramoino P., Milanese M., Candiani S., Diaspro A., Fato M., Usai C., Bonanno G., g-amino butyric acid (GABA) release in the ciliated protozoon Paramecium occurs by neuronal-like exocytosis. Journal of Experimental Biology, vol. 213, pp. 1251-1258, 2010.
  • Scaglione S., Zerega B., Badano R., Benatti U., Fato M., Quarto R., “A three-dimensional traction/torsion bioreactor system for tissue engineering”, International Journal of Artificial Organs, Vol. 33(6), pp. 362-369, 2010.
  • Ramoino P., Ledda FD, Ferrando S., Gallus L., Bianchini P., Diaspro A., Fato M., Tagliaferro G., Manconi R.; “Metabotropic y-aminobutyric acid (GABA(B)) receptors modulate feeding behavior in the calcisponge Leucandra aspera”, JOURNAL OF EXPERIMENTAL ZOOLOGY. PART A, ECOLOGICAL GENETICS AND PHYSIOLOGY, Vol. 315, pp. 132-140, 201
  • I Castiglioni, B Canesi, A Schenone, M Fato, D Perani, MC Gilardi, “Grid-distributed Statistical Parametric Mapping of SPECT and PET Neuroimages”, Neuroinformatics 9 (1), 85-90, 2011.
  • L. Corradi, I. Porro, A. Schenone, P. Momeni, R. Ferrari, F. Nobili, M. Ferrara, G. Arnulfo, M. M. Fato, “A repository based on a dynamically extensible data model supporting multidisciplinary research in neuroscience”, BMC medical informatics and decision making 12 (1), 115, 2012.
  • Izzo M., Mortola F., Arnulfo G., Fato M.M., Varesio L. “A digital repository with an extensible data model for biobanking and genomic analysis management”. BMC Genomics 2014, 15(Suppl 3):S3, doi:10.1186/1471-2164-15-S3-S3.
  • Arnulfo G., Narizzano M., Cardinale F., Fato M.M., Palva J.M., “Automatic Segmentationof Deep Intracerebral Electrodes in Computed Tomography Scans", BMC Bioinformatics 2015, 16(1):99,DOI 10.1186/s12859-015-0511-6.
  • Nicolò G Pozzi, Gabriele Arnulfo, Andrea Canessa, Frank Steigerwald, Robert Nickl, György A Homola, Marco M Fato, Cordula Matthies, Claudio Pacchetti, Jens Volkmann, Ioannis U Isaias, “Distinctive neuronal firing patterns in subterritories of the subthalamic nucleus”, Clinical Neurophysiology 127 (11), 3387-3393,, 2016.
  • M Cavo, M Fato, L Peñuela, F Beltrame, R Raiteri, S Scaglione , “Microenvironment complexity and matrix stiffness regulate breast cancer cell activity in a 3D in vitro model” Scientific Reports 6:35367, Oct 2016, , doi:10.1038/srep35367
  • Narizzano M., Arnulfo G., Ricci S., Toselli B., Canessa A., Tisdall M., Fato M. M., Cardinale F. “SEEG Assistant: a 3DSlicer extension to support epilepsy surgery” BMC Bioinformatics 18(1):124· 2017, DOI: 10.1186/s12859-017-1545-8.
  • M. Severino, D. Tortora, B. Toselli, S. Uccella, M. Traverso, G. Morana, V. Capra, E. Veneselli, M.M. Fato, and A. Rossi “Structural Connectivity Analysis in Children with Segmental Callosal Agenesis” AJNR Am J Neuroradiol 2017 38:639-647originally published online on January 19, 2017, 10.3174/ajnr.A5043.
  • Keyvan Mahjoory, Vadim V Nikulin, Loic Botrel, Klaus Linkenkaer-Hansen, Marco M Fato, Stefan Haufe, “Consistency of EEG source localization and connectivity estimates”, Neuroimage, Volume 152, 15 May 2017, Pages 590–601,
  • Canessa A., Gibaldi A., Chessa M., Fato M. M., Solari F., Sabatini S., “Data Descriptor: A dataset of stereoscopic images and ground-truth disparity mimicking human fixations in peripersonal space”, Scientific Data 4, Article number:170034 (2017) doi:10.1038/sdata.2017.34
  • Toselli, B., Tortora, D., Severino, M., Arnulfo, G., Canessa, A., Morana, G.,Rossi A., and Fato, M. M., “Improvement in White Matter Tract Reconstruction with Constrained Spherical Deconvolution and Track Density Mapping in Low Angular Resolution Data: A Pediatric Study and Literature Review”. Frontiers inPediatrics, V. 5, pp: 2296-2360,



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